Progesterone, a Look at the Oils

Glass Medicine Vials and Syringe

A surrogate will frequently be prescribed intramuscular injections of progesterone. The hormone is used to help aid in sustaining a pregnancy achieved through IVF and is typically given daily for the first ten to twelve weeks. The progesterone is mixed with an oil to create an injectable compound. There are several different types of oils that can be used for this process. Here’s a breakdown of the most commonly used oils for this purpose.

Ethyl Oleate- This is a type of oil you may not be familiar with. The fatty acid is created by the body when ethanol and oleic acid combine. It is, by far, the thinnest of the oil compounds for intramuscular injection. This allows for a smaller gauge injection needle.

Olive Oil– Olive oil is also commonly compounded with progesterone. While it is thicker than ethyl oleate, thus requiring a thicker needle, many women report that this blend offers some of the easiest absorption into the muscle.

Sesame Oil. This is oil tends to be a thinner compound than the olive oil blend. Typically, the thinner the oil the easier the absorption of the compound will be. Better absorption limits the size and sensitivity of the lumps which often form at the injection sites. Allergic reactions can occur with sesame oil, and in that instance the patient will often be switched to progesterone in a different oil base, typically ethyl oleate.

Peanut and Cottonseed Oils. These oils are typically used the least. Peanut oil tends to be rather thick and carries the potential for severe allergic reaction at the injection site. Cottonseed oil is a thinner compound and is reported to cause less intense pain at the injection site.

Doctors tend to prescribe a certain oil time and time again due to their personal preference. No one oil has shown to produce a significant benefit across the board when compared against another. While some patients report far less pain on one type of oil vs. another, a different woman may report experiencing the exact opposite reaction to the same oil compounds. More important than your oil type is ensuring that your injection site is properly identified and that you do not experience any allergic reactions. Your nurse can assist you in both of these areas.

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